臺北醫學大學 醫學院 國際醫學研究碩/博士學位學程

主題：

Topic

IFN-stimulated metabolite transporter ENT3 facilitates viral genome release

演講者：

Speaker

徐嘉琳 副教授  Associate Prof. Chia-Lin Hsu

國立陽明交通大學微生物及免疫學研究所
Institute of Microbiology and Immunology, National Yang-Ming  Chiao-Tung University

時間：

Date

112年5月4日(四) 上午10:00~12:00

May 4, 2023, 10:00-12:00

地點：

Venue

醫學綜合大樓後棟16樓 國際會議廳
International Conference Hall, 16F, Comprehensive Medical Building (Rear Building)

語言：
Language

中文 Chinese

主辦單位：
Organizer

醫學科學研究所
Graduate Institute of Medical Sciences, College of Medicine

共同主辦單位：
Co-Organizer

研究發展處
Office of Research and Development

演講摘要：
Abstract

An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this talk, we are going to discuss the findings that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Surprisingly, we unveil that several viruses, including SARSCoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.