拇山生物醫學研究講座
Moon-Shan biomedical research forum
本所訂於五月四日(四) 假醫學綜合大樓後棟16樓 國際會議廳舉辦『拇山生物醫學研究講座』,敬備茶水(請自備杯子),歡迎全校師生踴躍出席!
主題:
Topic
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IFN-stimulated metabolite transporter ENT3 facilitates viral genome release
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演講者:
Speaker
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徐嘉琳 副教授 Associate Prof. Chia-Lin Hsu
國立陽明交通大學微生物及免疫學研究所
Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University
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時間:
Date
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112年5月4日(四) 上午10:00~12:00
May 4, 2023, 10:00-12:00
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地點:
Venue
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醫學綜合大樓後棟16樓 國際會議廳
International Conference Hall, 16F, Comprehensive Medical Building (Rear Building)
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語言:
Language
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中文 Chinese
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主辦單位:
Organizer
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醫學科學研究所
Graduate Institute of Medical Sciences, College of Medicine
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共同主辦單位:
Co-Organizer
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研究發展處
Office of Research and Development
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演講摘要:
Abstract
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An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this talk, we are going to discuss the findings that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Surprisingly, we unveil that several viruses, including SARSCoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.
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